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Bungaro-toxin marker for histology

Bungaro-toxin marker for histology: A powerful tool for the quantification and evaluation of the Acetyl-Choline receptors on the NMJ. Dr. Emmanuel Loeb Introduction: The neuromuscular junction (NMJ) involves a complex structure whose function is to convey action potentials from the motorneuron (MN) to skeletal muscle, resulting in stimulated contraction of...

Webinar December 2020

Webinar December 2020 A professional Webinar on the topic: From a Conceptual “Idea” to a Marketed Product: Toxicology/Safety Assessment Pathology Regulatory Registration Webinar Video We discussed about: Introduction by Dr. Emmanuel Loeb, CEO, Patho-Logica, Inc. Definition and role of the various inter-related disciplines Safety assessment history (leading to the GLPs,...

CNS Models in Rodents

CNS models in rodents: What can you expect from your experimental pathologist? Dr. Emmanuel Loeb Introduction Three major parameters are important for accurate histopathological results in CNS models: Tissue preparation for representative lesion exposure and analysis. Choice of histological tools for measuring your desired end points. Accuracy of the analytical...

Calibration of IHC for Covid-19 virus

Calibration of IHC for Covid-19 virus in Golden Syrian Hamsters Dr. Emmanuel loeb, Dr. Zohar Gavish, Patho-Logica Ltd. Results: The objective was to detect a specific IHC signal in relevant structures of the lung in paraffin sections (4 microns thick). Two animal groups were examined: covid-19 intranasal infected hamsters and...

Digitalization of Pathology

How Artificial Intelligence (AI) and Deep Learning (DL) processes are shaping and influencing the work of the experimental pathologist.   Introduction Technology developments have changed and will continue to change many fields. When it comes to science and precise data, technology developments are becoming a real challenge for professionals such...

Treatment in Peripheral Nerve Injury

Photobiomodulation Triple Treatment in Peripheral Nerve Injury: Nerve and Muscle Response Mira M. Mandelbaum-Livnat, PhD,1 Mara Almog, PhD,1 Moshe Nissan, PhD,1 Emmanuel Loeb, DVM,2 Yuval Shapira, MD,1 and Shimon Rochkind, MD, PhD1 Abstract Background: Muscle preservation or decrease in muscle degeneration and progressive atrophy are major challenges in patients with...

Treatment of Experimental Actinic Keratoses

A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses Vered Behar, Hadas Pahima, Adi Kozminsky-Atias, Nir Arbel, Emmanuel Loeb, Max Herzberg and Oren M. Becker Overexpression of hexokinase 2, and its binding to VDAC1 on the outer mitochondrial membrane of cancer cells, is key to their metabolic reprogramming to...

The pros and cons of animal experiments

The pros and cons of animal experiments; an essay on ethical issues Author: Emmanuel Loeb As an experimental pathologist, I deal on a daily basis with tissue samples that were harvested during a controlled animal experiment, performed as part of the development process of new drugs and devices. In my...
Utilizing Patients-Derived Xenografts and Histological Assessment for Personized Medicine in Oncology

The Usage of Animal Models

The Usage of Animal Models for Pre-Clinical Trials: a pathological, comparative approach Author: Emmanuel Loeb. The utilazation of animal models offers the scientist a great opportunity to examine his developed product (drug or medical device) on a whole body system prior to the human trials. The animal model intends to...
The Usage of Animal Models for Pre-Clinical Trials: a pathological, comparative approach

Technocratic Scientific Empire

Technocratic Scientific Empire – the good, the bad, and the man that could not dream Author: Emmanuel Loeb We all live in a technocratic capitalistic world that demands innovation and advanced developments to improve health and quality of life, as well as to increase income and prosperity. If we compare...
Technocratic Scientific Empire – the good, the bad, and the man that could not dream

Utilizing Patients-Derived Xenografts

Utilizing Patients-Derived Xenografts and Histological Assessment for Personized Medicine in Oncology Author: Emmanuel Loeb Globally, 8.2 million people die each year from cancer, an estimated 13% of all deaths worldwide. There is a 70% increase in the expected new cases of cancer over the next 2 decades. According to the...
Utilizing Patients-Derived Xenografts and Histological Assessment for Personized Medicine in Oncology

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