"As to diseases make a habit of two things – to help or at least to do no harm" - Hippocrates , "Learn to see¸ learn to hear¸ learn to feel¸ learn to smell and know that by practice alone you can become an expert" – Sir William Olser , "Pathology is a nature. The diagnosis is a culture" – Utrecht University

Major fields of expertise

Central Nervous System

Central Nervous System

CNS models based on knowledge of the pathological mechanism of human diseases for ALS, Alzheimer’s disease, BBB Permeability, Epilepsy, Multiple Sclerosis, Parkinson disease, Stroke, Traumatic central and spinal cord injury, and Vascular dementia.

Oncology

Oncology

Treatments are tested in appropriate solid and metastatic tumor models related to the human tumor type, which include Blood (leukemia), Bone, Brain, Breast, Cervix, Colon, Liver, Ovary, Pancreas, Prostate, Skin (melanoma), and Urinary bladder.

Dermatology

Dermatology

Acute single-/ multi-dose models include Acne, Allergy (wheal formation), Delayed-type hypersensitivity, Dermal toxicity, Eye irritation, Itching, Psoriasis, Skin atrophy, Skin inflammation, Skin irritation, Skin sensitization, and Wound healing.

Stem Cells

Stem Cells

We are involved in many studies in this new developing field. Uses of stem cells include regenerative medicine in central and peripheral diseases, for which we have experience in models of Cardiovascular, Diabetes, Hind limb ischemia (angiogenesis), Multiple sclerosis, Osteoarthritis, Parkinson’s disease, Spinal cord injury, Stroke, Traumatic brain injury, and Wound healing.

Inflammation Immunology

Inflammation Immunology

Acute models include Carrageenan-induced paw edema and Formalin-induced acute inflammation. Chronic models include Inflammatory bowel disease, Multiple sclerosis (EAE). Osteoarthritis, and Rheumatoid Arthritis. Immunological models include LPS stimulation of murine macrophage cells. Studies employ immunohistochemistry tools for cellular identification and quantification.

POC (proof of concept)

POC (proof of concept)

These unique studies use the candidate treatment in a small experiment employing advanced technological tools as special markers and image analysis capabilities.
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