Following nearly two years of extensive work with our novel laser microtome system on resin-embedded (plastic-embedded) specimens, the system is now qualified for use in GLP-compliant studies. This capability enables us to incorporate the technique into studies intended for submission to regulatory authorities, such as the FDA, as part of our clients’ Investigational New Drug (IND) applications.
Advantages of using the laser based microtome sysytem:
Our laser microtome, the TissueSurgeon, offers contact-free, ultra-thin sectioning of plastic-embedded hard tissues and medical device implants. This technology eliminates the limitations of traditional methods of plastic embedded sections dissection, providing:
- Micron-Level Accuracy: Achieve section thicknesses ranging from 8 to 15 microns, ideal for detailed histological evaluation.
- Versatility: Suitable for a wide range of applications, including hard tissues such as bone pathology, dental and orthopedic implants, and regenerative medicine, implants and scaffolds.
- Artifact-Free Sections: Preserve tissue integrity and implant interfaces without the need for decalcification, ensuring high-quality histological images even at high magnifications.
- Enhanced Quality Control: Integrated Optical Coherence Tomography (OCT) allows for real-time quality assessment during sectioning.
- Enables the pathologist to evaluate the device–tissue interface using high-quality histological slides.
